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S. 545 Senate Crime and Law Enforcement

Combating Illicit Xylazine Act

Introduced
Feb 12, 2025
Sponsor
Sen. Cortez Masto, Catherine (D-NV)
View on Congress.gov (opens in a new tab)

STAGE 3 OF 8 — CALENDARS AND SCHEDULING

Currently in the Senate. Last action: placed on senate legislative calendar under general orders. calendar no. 372 on Apr 15, 2026.

  1. Senate Introduced in Senate Feb 12, 2025
  2. Senate Read twice and referred to the Committee on the Judiciary. Feb 12, 2025
  3. Senate Committee on the Judiciary. Ordered to be reported with an amendment in the nature of a substitute favorably. Mar 26, 2026
  4. Senate Committee on the Judiciary. Reported by Senator Grassley with an amendment in the nature of a substitute. Without written report. Apr 15, 2026
  5. Senate Placed on Senate Legislative Calendar under General Orders. Calendar No. 372. Apr 15, 2026

Cosponsors

35

Subjects

Congressional oversightConsumer affairsCriminal procedure and sentencingDrug safety, medical device, and laboratory regulationDrug trafficking and controlled substancesLicensing and registrationsManufacturingU.S. Sentencing CommissionVeterinary medicine and animal diseases

Committees

  • Judiciary Committee
    • [Markup By, Mar 26, 2026]
    • [Referred To, Feb 12, 2025]
    • [Referred To, Feb 12, 2025]

Summary

Combating Illicit Xylazine ActThis bill regulates xylazine under the Controlled Substances Act (CSA).Xylazine, also known as tranq, is a nonopioid sedative and pain reliever that is approved for use in animals. Recently, the Drug Enforcement Administration (DEA) has reported an increase in trafficking of fentanyl mixed with xylazine.This bill adds xylazine, including its salts, isomers, and salts of isomers, to schedule III of the CSA. Schedule III controlled substances, including anabolic steroids, buprenorphine, and ketamine, have less potential for abuse than a schedule I or II substance, have a currently accepted medical use, and have low or moderate risk of dependence if abused.Under the bill, manufacturing, distributing, or dispensing xylazine, or possessing with intent to manufacture, distribute, or dispense xylazine for illicit use is subject to criminal penalties under the CSA. The bill also requires xylazine transactions to be tracked in the drug reporting system maintained by the DEA.The bill exempts from registration under the CSA persons and entities that possess xylazine (1) lawfully dispensed by a veterinarian or pharmacy and (2) for an animal or for use in certain animal-control or wildlife programs.The bill also exempts xylazine manufacturers from the CSA's physical security requirements.Finally, the bill requires the DEA, in coordination with the Department of Health and Human Services (HHS), to provide Congress with a report on how the agencies previously determined whether xylazine should be a controlled substance, including the full text of HHS's recommendations to the DEA for scheduling xylazine.

[Summary as of: Reported to Senate]

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